Houston vs. Colorado odds, spread, prediction: 2026 college basketball picks for Feb. 28 from proven model

The fifth-ranked Houston Cougars look to put an end to a five-game losing streak when they take on the Colorado Buffaloes on Saturday afternoon. Houston has fallen short against Kansas, Arizona and Iowa State, all top-15 squads, in its last three games. The Cougars are 23-5 overall and remain in the Big 12 hunt at 11-4 in conference play. Colorado, meanwhile, is 16-12 overall with a 6-9 mark in the Big 12. 

Tipoff is at noon ET from the Fertitta Center in Houston. The Cougars are 18.5-point favorites in the latest Houston vs. Colorado odds, while the over/under is 141.5

Before making any Colorado vs. Houston picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated this matchup 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits nearly 60% of the time!

So who wins Houston vs. Colorado, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!