Houston vs. Butler odds, line, spread: Proven model reveals college basketball picks, predictions for Nov. 22, 2021

The No. 15 Houston Cougars will take on the Butler Bulldogs at 4:30 p.m. ET Monday at Michelob Ultra Arena. Butler is 3-1 while the Cougars are 3-0. Houston and Butler are both first in their respective divisions (the American Athletic and the Big East). 

The Cougars are favored by 10 points in the latest Houston vs. Butler odds from Caesars Sportsbook, and the over-under is set at 123. Before you make any Butler vs. Houston picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Houston vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Houston vs. Butler? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!