Houston vs. Arizona odds, prediction: 2026 Big 12 Conference Tournament men's college basketball picks from proven model

The top two teams in the Big 12 Conference clash when the second-seeded Houston Cougars meet the top-seeded Arizona Wildcats in Saturday's Big 12 Tournament championship game. Houston advanced to the title game with a 69-47 win over third-seeded Kansas in Friday's semifinals, while Arizona advanced with an 82-80 win over fifth-seeded Iowa State. The Cougars (28-5), who have won five in a row, are looking to win their second consecutive Big 12 Conference Tournament title. The Wildcats (31-2), who have won eight straight, finished runner-up last season after losing 72-64 to Houston in the 2025 title game.

Tip-off from the T-Mobile Center in Kansas City, Mo., is set for 6 p.m. ET. Arizona leads the all-time series 4-2, including a 73-66 win on Feb. 21. Arizona is a 2.5-point favorite in the latest Houston vs. Arizona odds from DraftKings Sportsbook, while the over/under for total points scored is 137.5. Before making any Houston vs. Arizona picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered conference tournament week on a sizzling 14-2 run on top-ranked over/under picks dating back to last year, and is on an 28-21 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Houston vs. Arizona 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 60% of simulations!

So who wins Houston vs. Arizona, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!