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Guardians vs. Nationals odds, line, start time, picks, best bets for May 7 matchup from proven model

SportsLine's projection model, which is on a 10-5 roll on top-rated MLB picks, has locked in its MLB picks for the Cleveland Guardians vs. Washington Nationals on Wednesday

By@SportsLineUpdated: May 07, 2025 7:11PM UTC . 2 min read

The Cleveland Guardians (21-15) and the Washington Nationals (17-20) wrap up their three-game series on Wednesday afternoon. They played in a doubleheader on Tuesday, with each team picking up a victory. Ben Lively (1-2, 3.72 ERA) starts for Cleveland. Brad Lord (1-3, 4.43 ERA) is on the hill for Washington. 

First pitch is scheduled for 12:05 p.m. ET at Nationals Park in Washington. The Guardians are the -119 money-line favorites (bet $119 to win $100) in the latest Guardians vs. Nationals odds, while the Nationals are -101 underdogs (bet $101 to win $100). The over/under for total runs scored is 9 in the latest MLB odds

Before you make any Guardians vs. Nationals picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 7 of the 2025 MLB season on a 10-5 run (67%) on top-rated MLB money-line picks. Anybody following could have seen strong returns!

The model has simulated Guardians vs. Nationals 10,000 times and the results are in. We can tell you the model is going Under on the run total, and it also says one side of the money line has all the value!

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