The Memphis Grizzlies and Milwaukee Bucks square off in a cross-conference matchup at 8 p.m. ET on Wednesday. Milwaukee is favored by 6.5 points at home, while the Over-Under is set at 226 (see up-to-date odds for every game this week on our NBA odds page). 

Before making any Grizzlies vs. Bucks picks, you NEED to check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 14 of the 2021-22 NBA season on a stunning 56-30 roll on all top-rated NBA picks, returning over $2,200. Anyone following it has seen HUGE returns.

The model knows the Grizzlies are in the top 10 of the NBA in offense and defense. Memphis excels on the offensive glass, securing 32.7 percent of missed shots, and the Grizzlies lead the NBA in second-chance points, fast-break points and points in the paint. Memphis is averaging more than 25 assists per game, with top-tier numbers in free-throw creation and turnover prevention. On defense, the Grizzlies lead the NBA in steals and blocks, with Memphis forcing 15.4 turnovers per game and holding opponents to 51.2 percent shooting on 2-point attempts.

The model also knows the Bucks are very good on offense, scoring 1.11 points per possession, but Milwaukee's bread is buttered on defense. The Bucks are in the top eight of the NBA in defensive rating, and Milwaukee holds opponents to 43.8 percent shooting and 33.9 percent on 3-point attempts. The Bucks are No. 6 in the NBA in free-throw attempts allowed, with an impressive defensive rebound rate of 73.4 percent. Milwaukee is in the top five in points allowed in the paint, with a top-10 mark in fast-break points allowed.

Now, it has set its sights on Grizzlies vs. Bucks. We can tell you the model is leaning under the total, and it also says one side of the spread hits in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any NBA picks.

Who wins Grizzlies vs. Bucks? And which side of the spread hits in well over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Grizzlies vs. Bucks spread you should be all over Wednesday, all from the model on a roll on NBA picks!