Giants vs. Tigers odds, line, start time, picks, best bets for May 26 matchup from proven model

The San Francisco Giants take on the Detroit Tigers in the first of a three-game series in a key interleague series on Monday. The Giants (31-22), who are second in the National League West, are 14-13 on the road in 2025. The Tigers (34-20), who lead the American League Central, are 18-8 on their home field.

First pitch from Comerica Park in Detroit is set for 1:10 p.m. ET. Detroit is a -111 favorite on the money line (risk $111 to win $100) in the latest Giants vs. Tigers odds, while the total number of runs Vegas thinks will be scored, or the Over/Under, is 8.5 in the latest MLB odds. 

Before you make any Giants vs. Tigers picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 10 of the 2025 MLB season on a profitable 27-21 run (56%) on top-rated MLB picks. Anybody following could have seen strong returns!

The model has simulated Giants vs. Tigers 10,000 times and the results are in. We can tell you the model is going Under on the run total, and it also says one side of the money line has all the value!

Who wins Giants vs. Tigers, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 27-21 roll on top-rated MLB picks!