Giants vs. Patriots prediction, line, odds: Proven model releases spread pick for 2025 NFL Week 13 Monday Night Football

A cross-conference matchup on 'Monday Night Football' in NFL Week 13 has the New England Patriots hosting the New York Giants. The Patriots (10-2) have the league's best record and are riding a nine-game win streak. The Giants (2-10) have the worst record in the NFC and have lost six in a row. Jaxson Dart (concussion) has cleared protocol will start for New York.

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

Kickoff is at 8:15 p.m. ET from Gillette Stadium in Foxborough, Mass. The latest Patriots vs. Giants odds have New England as the 7.5-point favorites, and the over/under for total points scored is 46.5.

Before making any Giants vs. Patriots picks, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 on a 49-33 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Patriots vs. Giants on 'Monday Night Football.'

We can tell you it's leaning Over the point total, but also says that one side of the spread hits well over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Giants vs. Patriots, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Patriots vs. Giants line to back, all from the model that has gone 49-33 on top-rated picks since 2024!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.