The Chicago Cubs look to derail the San Francisco Giants when they meet in a key matchup on Friday afternoon. The Giants (90-50) are looking to march to the National League West Division crown and lead the Los Angeles Dodgers by two games with just 22 games to play. The Cubs (65-76) are fourth in the NL Central. First pitch from Wrigley Field in Chicago is set for 2:20 p.m. ET.

The Giants are listed as -140 favorites (risk $140 to win $100) on the money line in the latest Giants vs. Cubs odds from Caesars Sportsbook, while the over-under for total runs scored is 9.5 (see the latest lines for every game on our MLB odds page).

Before making any Giants vs. Cubs picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every game 10,000 times, is 179-150 on top-rated MLB money-line picks through 23 weeks in the 2021 season, returning almost $500. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some HUGE returns!

Now, it has set its sights on Giants vs. Cubs. We can tell you the model is projecting 9.1 total runs, and it also says one side of the money line hits in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cubs vs. Giants? And which side of the money line hits in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Giants vs. Cubs money line you should be all over on Friday, all from the model that is 179-150 on top-rated MLB money-line picks in 2021!