Gardner-Webb vs. Charleston Southern odds, prediction: 2026 Big South Conference men's college basketball picks from proven model

The Gardner-Webb Runnin' Bulldogs look to snap a five-game skid when they face the Charleston Southern Buccaneers in a Big South Conference matchup on Tuesday. Gardner-Webb is coming off a 112-87 loss to High Point on Saturday, while Charleston Southern dropped a 90-80 decision at Radford that same day. The Runnin' Bulldogs (3-24, 1-11 Big South), who are ninth in the conference, are 0-13 on the road this year. The Buccaneers (12-15, 3-9 Big South), who are tied for seventh in the league, are 8-3 on their home court.

Tip-off from Buccaneer Field House in North Charleston, S.C., is set for 6 p.m. ET. Gardner-Webb leads the all-time series 25-12, but Charleston Southern has won the last three meetings, including 89-79 on Dec. 31. Gardner-Webb is a 17.5-point favorite in the latest Gardner-Webb vs. Charleston Southern odds from DraftKings Sportsbook, while the over/under for total points scored is 158.5. 

Before making any Gardner-Webb vs. Charleston Southern picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Gardner-Webb vs. Charleston Southern 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits more than 50% of the time!

So who wins Gardner-Webb vs. Charleston Southern, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!