The No. 8 Florida State Seminoles hit the road to take on the Virginia Cavaliers in an ACC showdown on Friday. FSU is 3-0 in 2025, with all three wins coming by 14 points or more. Transfer quarterback Tommy Castellanos has given the Noles a much-needed dynamic playmaker on the offensive side of the ball. The Cavaliers are 3-1 overall, and 1-0 in ACC play. The Wahoos are coming off a dominant 38-20 win over Stanford on Sept. 20. Florida State is 3-0 and Virginia is 3-1 against the spread this season.

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Kickoff at Scott Stadium in Charlottesville is scheduled for 7 p.m. ET. The Seminoles are a 7-point favorite in the latest Florida State vs. Virginia odds, while the over/under for total points scored is 60.5. FSU is a -265 (risk $265 to win $100) favorite on the money line, with Virginia listed as a +215 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Wyoming vs. Colorado picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 242-166-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 103.81 units ($10,381.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for Florida State vs. Virginia in their Week 5 matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Virginia vs. Florida State in their Week 5 matchup at Scott Stadium in Charlottesville and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 242-166-7, returning $10,382 for $100 bettors, betting on college football since 2023, and find out!

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