The No. 9 Duke Blue Devils host the Florida State Seminoles on Saturday in an Atlantic Coast Conference matchup at Cameron Indoor Stadium. Duke (22-4, 12-3) lost the last meeting 79-78 in overtime last month, but it has lost just one game since. Depleted FSU (13-11, 6-8) comes in having lost six of its past seven games. 

Tipoff is set for 6 p.m. ET in Durham, N.C. Duke is favored by 15 points at Caesars Sportsbook, while the Over-Under is set at 142.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Duke vs. Florida State picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Duke is a strong team on both ends of the court, and it has won eight of its past nine games. It scores just under 80 points per game (21st in DIvision I) and gives up just over 65 points (65th). The Seminoles have struggled defensively, allowing more than 70 points (234th) and several key players have injury concerns. They are relying on a bevy of big men, so a strong-shooting Duke team (19th overall, 49th on 3-pointers) should have a lot of open shots away from the rim.     

Florida State comes in with a chip on its shoulder after a dismal run. But it snapped its six-game losing streak with an 81-80 victory against Clemson on Tuesday night. It is trotting out several 7-footers in the absence of its top stars, so it could provide a major matchup problem for the Blue Devils. Tanor Ngom (7-foot-2) blocked three shots against Clemson. Matt Cleveland (10.6 points) is the top available scorer, and Cam'Ron Fletcher had 17 off the bench Tuesday. 

Now, it has set its sights on Duke vs. Florida State. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Saturday's Duke vs. Florida State ACC matchup? And which side of the spread hits in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the FSU vs. Duke spread you should be all over Saturday, all from the model on a roll on college basketball picks!