Florida International vs. Texas-San Antonio odds, line: 2025 college football picks for First Responder Bowl matchup from proven model

The Florida International Panthers meet the Texas-San Antonio Roadrunners in the 2025 First Responder Bowl on Friday night. FIU is coming off a 56-16 win at Sam Houston State on Nov. 29, while UTSA dropped a 27-24 decision to Army that same day. FIU (7-5), who finished tied for fourth in Conference USA at 5-3, have won four in a row. UTSA (6-6), who tied for sixth in the American Conference, have won two of three.

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Both teams will be without multiple players due to injury or the transfer portal. The Panthers will be extremely shorthanded in the secondary and have questions at quarterback, where Keyone Jenkins and Joe Pesansky are expected to split snaps.

Kickoff from Gerald J. Ford Stadium in Dallas is at 8 p.m. ET. The Roadrunners are 7-point favorites in the latest FIU vs. UTSA odds, while the over/under for total points scored is 61.5 via SportsLine consensus. 

Before making any FIU vs. UTSA picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

The model has simulated FIU vs. UTSA 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins FIU vs. UTSA, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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