The Week 5 Fantasy football rankings have massive shake-ups with not only four teams on byes but with star players getting injured. Malik Nabers is done for the season, as is Tyreek Hill. Then there's Lamar Jackson, who left last week's game early, and now has been ruled out for Week 5 Fantasy football lineups. Jackson's injury could be a one-week thing or a multi-game situation, which throws the Fantasy football strategy for his owners in a flux. Meanwhile, Arizona's Trey Benson was placed on IR, and Tampa's Bucky Irving is out as well, and Vegas' Brock Bowers is trending to be sidelined as well.

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Players like Drake Maye, Javonte Williams and Quentin Johnston have been top 10 players in positional rankings, but can their production maintain? We've mentioned the injuries, but how will those players on byes affect who you utilize as Week 5 Fantasy football picks?

Before setting your Fantasy football lineups, you NEED to see the Week 5 Fantasy football rankings from SportsLine's advanced computer model. 

When it comes to ranking players, SportsLine's model beat human experts for the past several seasons, especially when there were big differences in ranking! That could literally be the difference between winning your league or going home empty-handed.

Now the model, which simulates every NFL game 10,000 times, has revealed its latest Week 5 Fantasy football rankings.

One player the model is high on this week: Colts quarterback Daniel Jones. And a massive shocker: Eagles receiver DeVonta Smith, a two-time 1,000-yard wideout, may not warrant a spot in Week 5 Fantasy football lineups as he sits outside the top 30 in positional rankings! He's a player to fade this week.

The model is also calling for a SHOCKING running back you aren't even thinking about to finish in the top five of its Week 5 Fantasy football rankings! This pick could be the difference between winning BIG and going home with nothing. You ABSOLUTELY need to see who it is before locking in your lineups.

So who should you start and sit in Week 5, and which surprising running back could lead you to victory? ... Join SportsLine now to get Week 5 Fantasy football rankings for every single position, and see which shocking running back comes out of nowhere to crack the top 5, all from the model that has out-performed experts big-time!

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