Fantasy football rankings: 2025 NFL Week 16 projections from proven model that outperformed experts

Two defenses have been targeted like no others when it comes to making Fantasy football picks. The Cowboys have allowed the most Fantasy points to both quarterbacks and receivers, while the Bengals have allowed the most Fantasy points to both running backs and tight ends. So, obvious Week 16 Fantasy football advice would be to load up your Week 16 Fantasy football lineups with players opposing those teams. Dallas takes on the Chargers, while Cincy will face Miami, both on Sunday.

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So, Justin Herbert, along with Keenan Allen and Ladd McConkey may get a boost in the Week 16 Fantasy football rankings opposite of the Cowboys defense. Meanwhile, De'Von Achane was already a must-start, but Jaylen Wright and Ollie Gordon also deserve consideration, as does Darren Waller at tight end. While knowing which defenses are Fantasy-friendly is certainly helpful, your Week 16 Fantasy football strategy wouldn't be complete without knowing which defenses you may want to avoid when making picks.

Before setting your Fantasy football lineups, you NEED to see the Week 16 Fantasy football rankings from SportsLine's advanced computer model. 

When it comes to ranking players, SportsLine's model beat human experts for the past several seasons, especially when there were big differences in ranking! That could literally be the difference between winning your league or going home empty-handed.

Now the model, which simulates every NFL game 10,000 times, has revealed its latest Week 16 Fantasy football rankings.

One player the model is high on this week: Broncos quarterback Bo Nix, despite him having one or fewer passing TDs in four of his last five games and being started in just 43% of leagues this week. And a massive shocker: Giants receiver Wan'Dale Robinson, who is averaging 81.3 yards with two scores over his last three games, and is the WR9 in PPR leagues, may not warrant a spot in Week 16 Fantasy football lineups. Robinson sits outside the top 30 in wide receiver rankings due to a tough Sunday matchup versus Minnesota's No. 5 passing defense!

The model is also calling for a SHOCKING wideout you aren't even thinking about to finish in the top 15 of its Week 16 Fantasy football rankings, even slotted ahead the likes of Justin Jefferson and D.K. Metcalf! This pick could be the difference between winning BIG and going home with nothing. You ABSOLUTELY need to see who it is before locking in your lineups.

So who should you start and sit in Week 16, and which surprising wide receiver could lead you to victory? ... Join SportsLine now to get Week 16 Fantasy football rankings for every single position, and see which shocking wideout comes out of nowhere to crack the top 15, all from the model that has out-performed experts big-time!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.