Cardinals running back James Conner (knee), Dolphins running back De'Von Achane (knee), and Vikings star receiver Justin Jefferson (hamstring) were placed on IR this week, creating difficult Fantasy football start-sit decisions. There are also plenty of Fantasy football injuries to consider, like Saquon Barkley (ankle), Marquise Brown (illness), and Sam LaPorta (calf).

Before setting your Week 6 Fantasy football lineups for the 2023 NFL season, you NEED to see what SportsLine's advanced computer model has to say. When it comes to ranking players, SportsLine's model beat human experts for the past several seasons, especially when there were big differences in ranking! That could literally be the difference between winning your league or going home empty-handed.

Now the model, which simulates every NFL game 10,000 times, has revealed its latest Week 6 Fantasy football rankings.

One player the model is high on this week: Vikings receiver Jordan Addison. And a massive shocker: Eagles wide receiver DeVonta Smith, who had his first 1,000-yard season last year and was started in 95% of CBS Sports Fantasy football leagues last week, stumbles big-time and doesn't even crack the top 25 at his position! He's a player to consider leaving on the bench.

The model is also calling for a UNDERRATED running back to finish in the top five of its Fantasy football rankings, ahead of players like Alvin Kamara and Derrick Henry! These picks could be the difference between winning BIG and going home with nothing. You ABSOLUTELY need to see who it is before locking in your lineups.

So who should you start and sit in Week 6? And which underrated running back could lead you to victory? ... Join SportsLine now to get Fantasy football rankings for every single position, and see which shocking running back comes out of nowhere to crack the top five, all from the model that has out-performed experts big-time!