English Premier League Manchester City vs. Tottenham odds, predictions: Picks and best bets for Sunday's opener from proven soccer guru

League champion Manchester City begins defense of its title with a road matchup against Tottenham Hotspur on Sunday as the teams kick off their 2021-22 English Premier League seasons. City dominated during the regular season, going 27-5-6 to finish 12 points clear at the top of the table. Spurs (18-8-12) finished a disappointing seventh and come in with a new manager as star Harry Kane pushes for a transfer out. 

Kickoff from Tottenham Hotspur Stadium is set for 11:30 a.m ET. Caesars Sportsbook lists City as the -160 favorite (risk $160 to win $100) in its latest Tottenham vs. Manchester City odds, with Spurs the +470 underdog and a draw priced at +285. The over-under for total goals scored is set at 2.5. (For the latest soccer news and analysis, click here)

Proven soccer expert Martin Green has revealed his best bets for the Tottenham vs. Manchester City matchup below, and bettors who have followed his advice have cashed in huge. Green is a handicapper who has  covered the game worldwide, and his European soccer picks have generated more than $36,000 for $100 bettors since the 2017-18 season. 

Green has taken an in-depth look at the Tottenham vs. Manchester City matchup, and is revealing two confident best bets and has a full breakdown of this Premier League showdown! You ABSOLUTELY need to see his picks and analysis before making any selections of your own.

What are the best bets you can make on the Tottenham vs. Manchester City match on Sunday? ... Join SportsLine now to see Martin Green's best bets on the Tottenham vs. Manchester City matchup, all from the soccer insider who's generated more than $36,000 for $100 bettors since the 2017-18 season!