East Carolina vs. South Carolina odds, line, spread: Proven model reveals college football picks, predictions for Week 2, 2021

The East Carolina Pirates will take on the South Carolina Gamecocks at noon ET on Saturday at Dowdy-Ficklen Stadium. The Pirates are 0-1, while USC is 1-0. The Gamecocks ended last year sixth in the SEC East, while East Carolina ended up eighth in the AAC. 

The Gamecocks are favored by 2.5 points in the latest East Carolina vs. South Carolina odds from Caesars Sportsbook, and the over-under is set at 56.5. Before making any South Carolina vs. East Carolina picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated East Carolina vs. South Carolina 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins East Carolina vs. South Carolina? And which side of the spread has all the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks. .. If you're already a member, see the picks below!