The Philadelphia Eagles will begin their title defense when they host the Dallas Cowboys in the 2025 NFL Kickoff Game on Thursday. Philadelphia denied Kansas City a three-peat when it cruised to a 40-22 win in February's Super Bowl, securing the franchise's second Super Bowl. Dallas missed the postseason last year and is hoping to bounce back in 2025, though the Cowboys did trade away Micah Parsons just one week before the opener. The Eagles have won three straight home games over Dallas and five of the last six in Philadelphia, but the Cowboys lead the all-time series.

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Kickoff from Lincoln Financial Field in Philadelphia is set for 8:20 p.m. ET. Philadelphia is an 8-point favorite in the latest Eagles vs. Cowboys odds, while the over/under for total points scored is 47.5. Philly is at -448 on the money line (risk $448 to win $100), while Dallas is the +347 underdog (risk $100 to win $347).

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