Eagles vs. Commanders prediction, odds: Proven model releases 2025 NFL Week 16 picks for Saturday matchup

A pair of NFC East rivals will meet for the 184th time when the Philadelphia Eagles visit the Washington Commanders on Saturday. Philly (9-5) ended a three-game losing streak with a 31-0 shutout victory over Las Vegas on Sunday. Washington (4-10) ended an eight-game losing streak by defeating the Giants, 29-21, in Week 15. The Eagles can clinch the NFC East with a victory, while Washington is sitting Jayden Daniels for the rest of the season.

Kickoff is at 5 p.m. ET from Northwest Stadium in Landover, Md. The Commanders lead the all-time series 90-87-6. Philadelphia is the 6.5-point favorite in the latest Eagles vs. Commanders odds, while the over/under for total points scored is 44.5.

Before making any Commanders vs. Eagles picks, or 2025 NFL Week 16 predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Eagles vs. Commanders.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits well over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Commanders vs. Eagles in NFL Week 16, and which side of the spread hits well over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Eagles vs. Commanders line to back, all from the model that has gone 52-37 on top-rated picks since 2024!

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