Eagles vs. 49ers prediction, odds: Proven model releases 2026 NFL Wild Card picks for Sunday matchup

The middle matchup of the three-game NFL Wild Card Sunday slate has the Philadelphia Eagles hosting the San Francisco 49ers. Philly (11-6) is the No. 3 seed after winning the NFC East and has won three of its last four games. San Fran (12-5) is the 6-seed and saw a six-game win streak come to an end last Saturday. One of these teams has represented the NFC in the Super Bowl five times over the last eight years.

Kickoff is at 4:30 p.m. ET from Lincoln Financial Field in Philadelphia. The Niners lead the all-time series 21-15-1. The latest Eagles vs. 49ers odds have Philadelphia favored by 4.5 points, while the over/under for total points is 44.5. 

Before making any 49ers vs. Eagles picks, or 2026 NFL playoff predictions of your own, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Wild Card Weekend on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Eagles vs. 49ers.

We can tell you it's leaning Over the point total, but also says that one side of the spread hits in over 50% of simulations! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins 49ers vs. Eagles on Wild Card Weekend, and which side of the spread hits over 50% of the time? ... Join SportsLine RIGHT NOW to see which side of the Eagles vs. 49ers line to back, all from the model that has gone 53-37 on top-rated picks since 2024!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW.