Duke vs. Syracuse odds, prediction: 2026 ACC men's college basketball picks from proven model

A pair of ACC squads aiming for their third straight victories will clash on Monday's college basketball schedule as the Duke Blue Devils host the Syracuse Orange. No. 4 Duke (23-2, 12-1 ACC) is coming off a Saturday win over Clemson to maintain its spot atop the conference standings. Syracuse (15-11, 6-7 ACC) secured a one-point win over SMU on Feb. 14 following an overtime victory over Cal. The Blue Devils are 17-6 all-time versus the Orange, including 10 straight victories.

Tipoff is at 7 p.m. ET from Cameron Indoor Stadium in Durham, N.C. The Blue Devils are 20.5-point favorites in the latest Syracuse vs. Duke odds from DraftKings Sportsbook, while the over/under for total points scored is 143.5.

Before making any Duke vs. Syracuse picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 15 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 11-5 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Syracuse vs. Duke 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Duke vs. Syracuse, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the Syracuse vs. Duke spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!