The newly minted No. 1 Duke Blue Devils (7-0) face a tough test right off the bat when they visit Columbus, Ohio on Tuesday to face the Ohio State Buckeyes (4-2) in a 2021 ACC/Big Ten Challenge matchup. This is the first nonconference road game for the Blue Devils in almost two years. 

Tip-off is set for 9:30 p.m. ET at Value City Arena. The Blue Devils are a three-point favorite in the latest Duke vs. Ohio State college basketball odds from Caesars Sportsbook, while the Over-Under is set at 147. Before making any Ohio State vs. Duke picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model. 

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model has factored in that the Blue Devils are coming off a huge 84-81 win against No. 1 Gonzaga. Forwards Wendell Moore and Paolo Banchero combined for 41 points in that game, and center Mark Williams had 17 points and nine rebounds. They are among the five Blue Devils scoring at least nine points, led by Banchero at 18.3. Duke is averaging 85.6 points per game (19th in Division I), 10 points more than Ohio State, which also gives up 69.3 points (198th).

The simulations also have taken into account that the Buckeyes are without Justice Sueing but are still a dangerous team. Forward E.J. Liddell has carried the load with Sueing missing with an abdominal injury, and he is scoring 22.5 points per game. Ohio State is off to an up-and-down start, with a victory against Seton Hall and single-digit losses to Xavier and Florida. The Buckeyes shoot 47.6 percent from the field (64th in nation) and 37.3 from three-point range (75th).

Now, the model has set its sights on Tuesday's Duke vs. Ohio State matchup in the ACC/Big Ten Challenge. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins the Duke vs. Ohio State matchup on Tuesday? And which side of the spread hits in over 50 percent of simulations? ... Join SportsLine right now to find out which side of the Ohio State vs. Duke spread you should be all over Tuesday, all from the model on a roll on college basketball picks!