Duke vs. North Carolina odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

The fourth-ranked Duke Blue Devils will look to stay perfect in Atlantic Coast Conference play when they face the 14th-ranked North Carolina Tar Heels in a key matchup on Saturday night. Duke is coming off a 67-49 win over Boston College on Tuesday, while North Carolina defeated Syracuse 87-77 on Monday. The Blue Devils (21-1, 10-0 ACC), who lead the conference by one game over No. 20 Clemson, are 7-0 on the road this season. The Tar Heels (18-4, 6-3 ACC), who are tied for fifth in the league, are 13-0 on their home floor.

Tipoff from the Dean E. Smith Center in Chapel Hill, N.C., is set for 6:30 p.m. ET. North Carolina leads the all-time series 145-120. Duke is a 5.5-point favorite in the latest Duke vs. North Carolina odds from DraftKings Sportsbook, while the over/under for total points scored is 151.5. 

Before making any Duke vs. North Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 14 on a sizzling 10-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 8-1 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

The model has simulated Duke vs. North Carolina 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Duke vs. North Carolina, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!