Duke vs. North Carolina odds, prediction: 2026 ACC picks for March 7 from proven model

One of the greatest rivalries in college basketball unfolds another chapter on Saturday when the top-ranked Duke Blue Devils host the No. 17 North Carolina Tar Heels in a Tobacco Road Rivalry matchup. UNC stunned the Blue Devils in their first meeting this year, but Duke has rolled since that point. UNC also lost top player Caleb Wilson (thumb) since that point, so the Tar Heels will have their work cut out if they want to sweep the series this season.

Tipoff from Cameron Indoor Stadium is set for 6:30 p.m. ET. Duke is a 17.5-point favorite in the latest UNC vs. Duke odds, while the over/under is 146.5. 

Before making any Duke vs. North Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered Week 18 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 23-17 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Duke vs. UNC 10,000 times and the results are in. The model is going Over, and it also says one side of the spread hits nearly 60% of the time!

So who wins Duke vs. UNC, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!