Duke vs. Louisville odds, prediction: 2026 men's college basketball picks for Jan. 6 from proven model

A pair of ranked ACC squads will meet on Tuesday as the Duke Blue Devils visit the Louisville Cardinals. No. 6 Duke (13-1, 2-0 ACC) is coming off a 91-87 win over Florida State, which followed a six-point win over Georgia Tech in its conference opener. No. 20 Louisville (11-3, 1-1 ACC) suffered an 80-76 defeat to Stanford on Friday after rolling over Cal by 20 points in its first ACC contest. The Blue Devils have won seven straight meetings with the Cardinals.

Tipoff is at 7 p.m. ET from the KFC Yum! Center in Louisville, Ky. The Cardinals are 1.5-point favorites per the latest Louisville vs. Duke odds, while the over/under for total points is 161.5.

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Before making any Duke vs. Louisville picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and enters Week 10 on a sizzling 9-1 run on top-ranked over/under picks dating back to last year. Anyone following could have seen HUGE returns!

The model has simulated Louisville vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in nearly 60% of simulations!

So who wins Duke vs. Louisville, and which side hits in nearly 60% of simulations? Join SportsLine right now to see which side of the Louisville vs. Duke spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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