Duke vs. Lafayette odds, line, spread: Proven model reveals college basketball picks, predictions for Nov 19, 2021

The No. 7 Duke Blue Devils have a couple of warmup games left before premier matchups against No. 1 Gonzaga and No. 19 Ohio State at the end of November. On Friday, Duke hosts the Lafayette Leopards at 8 p.m. ET. Duke is 4-0 and coming off of a 40-point win against Gardner-Webb on November 16, 92-52. Lafayette (0-3) has yet to win a game, and opened the season against another ACC opponent in Syracuse, which ended in a 97-63 loss.

The Blue Devils are favored by 32.5 points in the latest Duke vs. Lafayette odds from Caesars Sportsbook, and the over-under is set at 147.5. Before you make any Lafayette vs. Duke picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Duke vs. Lafayette 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 70 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Duke vs. Lafayette? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks ... If you're already a member, see the picks below!