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Dodgers vs. Guardians odds, line, start time, picks, best bets for May 27 matchup from proven model

SportsLine's projection model, which is on a 27-21 roll on top-rated MLB picks, has locked in its MLB picks for the Dodgers vs. Guardians on Tuesday

By@SportsLineUpdated: May 27, 2025 8:26PM UTC . 2 min read

The Los Angeles Dodgers (33-21) and the Cleveland Guardians (29-24) square off in an interleague contest on Tuesday. These teams matched up in Game 1 of the series yesterday, where the Dodgers beat the Guardians 7-2. Dustin May (2-4, 4.09 ERA) is on the hill for Los Angeles. Tanner Bibee (4-4, 3.57 ERA) gets the start for Cleveland.

First pitch is scheduled for 6:10 p.m. ET at Progressive Field in Cleveland. The Dodgers are the -128 money-line favorites (bet $128 to win $100) in the latest Dodgers vs. Guardians odds, while the Guardians are +109 underdogs (bet $100 to win $109). The Over/Under for total runs scored is 9 in the latest MLB odds. 

Before you make any Dodgers vs. Guardians picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 10 of the 2025 MLB season on a profitable 27-21 run (56%) on top-rated MLB picks. Anybody following could have seen strong returns!

The model has simulated Dodgers vs. Guardians 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

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