Dodgers vs. Diamondbacks odds, line, prediction: 2026 MLB Opening Day picks from proven model

The reigning champion Los Angeles Dodgers will begin defense of their title on 2026 MLB Opening Day with a matchup with the Arizona Diamondbacks on Thursday. Los Angeles (93-69) is aiming to end the year with the first MLB three-peat since the Yankees (1998-2000). The Diamondbacks (80-82) are hoping to end the season with a postseason appearance after missing out on the last two years, which came after a World Series appearance in 2023. L.A. will start Yoshinobu Yamamoto (12-8, 2.49 ERA), while the Dbacks will roll with Zac Gallen (13-15, 4.83 ERA).

First pitch is at 8:30 p.m. ET from Dodger Stadium in Los Angeles. The latest Dodgers vs. Diamondbacks odds list L.A. as the -258 favorite on the money line (risk $258 to win $100). The over/under for total runs is 8.5.

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The model has simulated Dodgers vs. Diamondbacks 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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