Diamondbacks vs. White Sox odds, line, start time, picks, best bets for June 25 matchup from proven model

The Arizona Diamondbacks (41-38) and the Chicago White Sox (25-55) link up to close out the three-game series on Wednesday. The Diamondbacks go for the sweep over the White Sox after winning Games 1 and 2. They secured a 4-1 victory over Chicago on Tuesday evening. 

First pitch is scheduled for 2:10 p.m. ET at Rate Field in Chicago. The Diamondbacks are the -153 money-line favorites (bet $153 to win $100) in the latest Diamondbacks vs. White Sox odds, while the White Sox are +128 underdogs (bet $100 to win $128). The over/under for total runs scored is 8.5 in the latest MLB odds. 

Before you make any Diamondbacks vs. White Sox picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 14 of the 2025 MLB season on a profitable 41-32 run on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 22 units of profit. Anybody following could have seen strong returns!

The model has simulated Diamondbacks vs. White Sox 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Diamondbacks vs. White Sox, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 41-32 roll on top-rated MLB picks!