DePaul vs. Creighton odds, line, spread: Proven model reveals college basketball picks, predictions for Feb 17, 2022

The Creighton Bluejays still have a chance to improve their place in the Big East standings before the end of the regular season, and their next opportunity comes on Thursday night at DePaul. The Blue Demons are just 3-11 in conference play, but 9-6 at home on the season, while Creighton is 16-8 overall but just 4-4 on the road. Creighton won handily at home in their previous meeting this season on January 22, 60-47.

Tip-off from Wintrust Arena is set for 10 p.m. ET, and can be seen live on CBS Sports Network. The Blue Demons are favored by two points in the latest DePaul vs. Creighton odds from Caesars Sportsbook, with the over-under set at 140. Before you make any Creighton vs. DePaul picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated DePaul vs. Creighton 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins DePaul vs. Creighton? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks ... If you're already a member, see the picks below!