A Big East battle is on tap between the DePaul Blue Demons and the Butler Bulldogs at 8:30 p.m. ET on Wednesday at Wintrust Arena. DePaul is riding an eight-game losing streak following Saturday's 82-68 loss at then-No. 16 Xavier. The Blue Demons are favored by 2.5 points in the latest DePaul vs. Butler odds from Caesars Sportsbook, while the over/under is set at 138.5. 

Before you make any Butler vs. DePaul picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 16 of the season 71-42 on all-top rated college basketball picks this season, returning more than $1,700 for $100 players. Anybody who has followed it has seen huge returns.

Now, it has simulated DePaul vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins DePaul vs. Butler? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!