The New York Yankees will look to extend their winning streak to five games when they battle the Chicago Cubs in a key interleague series starting on Friday. The Cubs (55-38), who are first in the National League Central, are 25-22 on the road in 2025. The Yankees (52-41), who are second in the American League East, are 29-17 on their home field this season.

First pitch from Yankee Stadium in New York is set for 7:05 p.m. ET. The Yankees have won seven of the last 10 meetings with the Cubs. New York is a -178 favorite on the money line (risk $178 to win $100) in the latest Cubs vs. Yankees odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9 in the latest MLB odds. Chicago's Pete Crow-Armstrong is +425 to hit a home run, while Kyle Tucker is +160 to record 1+ RBI. 

Before you make any Cubs vs. Yankees picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 16 of the 2025 MLB season 45-38 on top-rated MLB picks. It has excelled making home run prop picks this season, returning more than 28 units of profit. Anybody following could have seen strong returns!

The model has simulated Cubs vs. Yankees 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Cubs vs. Yankees, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 45-38 roll on top-rated MLB picks!