Creighton vs. UConn odds, prediction: 2026 Big East Conference men's college basketball picks from proven model

The Creighton Bluejays look to snap a two-game losing skid when they take on the fifth-ranked Connecticut Huskies in a key Big East Conference matchup on Wednesday. Creighton is coming off an 80-69 loss to Villanova on Saturday, while UConn slipped past Georgetown 79-75 that same day. The Bluejays (13-13, 7-8 Big East), who are 0-3 against ranked opponents in 2025-26, are 2-7 on the road this season. The Huskies (24-2, 14-1 Big East), who are 19-0 against unranked foes, are 13-1 on their home floor.

Tip-off from Gampel Pavilion in Storrs, Conn., is set for 7 p.m. ET. Creighton leads the all-time series 9-4, but UConn earned an 85-58 win on Jan. 31 at Creighton. UConn is a 16.5-point favorite in the latest Creighton vs. UConn odds from DraftKings Sportsbook, while the over/under for total points scored is 142.5. Before making any Creighton vs. UConn picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Creighton vs. UConn 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 60% of the time!

So who wins Creighton vs. UConn, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!