The defending Super Bowl champion Philadelphia Eagles begin their title defense against their fiercest rivals in the Dallas Cowboys in an NFL Kickoff Game matchup on Thursday, Sept. 4. The Cowboys (7-10 in 2024) are looking to bounce back after finishing first in the division in 2023, with a 12-5 mark, but they'll have to do it without Micah Parsons after trading the star defender to the Packers. The Eagles (14-3 in 2024), who won the NFC East for the second time in three years, are looking to become the first back-to-back winner in the division since Philadelphia won four consecutive NFC East titles from 2001 to 2004.

Kickoff from Lincoln Financial Field in Philadelphia is set for 8:20 p.m. ET. This is the first Week 1 meeting between the teams in 25 years, and the Cowboys lead the all-time series 74-58, but the Eagles have won three straight matchups at home. Philadelphia is an 8-point favorite in the latest Cowboys vs. Eagles odds, while the over/under for total points scored is 47.5. The Eagles are -448 on the money line (risk $448 to win $100), while Dallas is at +347 (risk $100 to win $347).

Before making any Cowboys vs. Eagles picks or 2025 NFL Kickoff Game predictions of your own, you NEED to see which side SportsLine NFL expert Matt Severance is on.

Severance is a well-connected writer and high-volume handicapper who has worked in the industry since 2005. He went 121-93-2 for a profit of $589 on his NFL spread picks last season, and is 37-12 (+1938) on his last 49 NFL money line picks. He is also an amazing 24-10-1 (+1431) in his last 35 picks in Eagles games. Anybody following him could be WAY UP!

Now, Severance has locked in another confident money-line pick for Cowboys vs. Eagles at the NFL Kickoff Game 2025.

We can tell you he's leaning Over the point total, but he also knows a crucial X-factor makes one side of the money line a MUST-BACK! You ABSOLUTELY NEED to see what it is before locking in any picks of your own.

So who wins Cowboys vs. Eagles in the 2025 Pro Football Hall of Fame Game? ... Join SportsLine RIGHT NOW to see which side of the Cowboys vs. Eagles ML to take, all from the expert who is an AMAZING 24-10-1 (+1431) in his last 35 picks in Eagles games!