Cowboys vs. Chiefs prediction, line, odds: Proven model releases NFL picks, best bets for Thanksgiving Day matchup

Two teams fighting for their playoff lives will meet in the second NFL game on Thanksgiving Day as the Dallas Cowboys host the Kansas City Chiefs. Dallas (5-5-1) is coming off back-to-back victories, including a 24-21 win over Philadelphia in Week 12 to get back to .500. Kansas City (6-5) ended a two-game losing streak with a 23-20 triumph over Indianapolis on Sunday. The Cowboys lead the all-time series, 7-5, but the Chiefs won the last meeting in 2021. Offensive lineman Trey Smith (ankle) and tight end Noah Gray (concussion) have both been ruled out for Kansas City, but Isiah Pacheco (knee) will return. Cowboys OL Tyler Guyton (ankle) is out.

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Kickoff is from AT&T Stadium in Arlington, Texas, at 4:30 p.m. ET on CBS and Paramount+, where, for a limited time, you can get your first two months for $2.99/month. The latest Cowboys vs. Chiefs odds have Kansas City as the 3.5-point favorites. The over/under for total points scored is 53.5. The Chiefs are at -190 on the money line (risk $190 to win $100), with the Cowboys at +159 (risk $100 to win $159).

Before making any Chiefs vs. Cowboys picks or NFL predictions, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 13 on a 49-33 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Cowboys vs. Chiefs on Thanksgiving Day.

We can tell you the model is going Under the point total, but also says one side of the spread hits well over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Chiefs vs. Cowboys on Thanksgiving, and which side of the spread hits in well over 50% of simulations? ... Join SportsLine RIGHT NOW to see which side of the Cowboys vs. Chiefs line to back, all from the model that is 49-33 on top-rated picks since 2024!

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