Colts vs. Chargers: 2022 Week 16 Monday Night Football proven expert predictions including model simulation, DFS picks, best bets

The Los Angeles Chargers can clinch a playoff spot for the first time since 2018 with a victory on Monday night against the Indianapolis Colts. LA is 8-6 and enters off a 17-14 win over Tennessee, while Indianapolis, 4-9, set an NFL record by blowing a 33-0 lead and losing 39-36 last Saturday against Minnesota. The teams last played in 2019 when the Chargers won in overtime, 30-24. Los Angeles is favored by 4 in the latest Chargers vs. Colts odds from Caesars Sportsbook and the over/under is set at 45.5 Kickoff is scheduled for 8:15 p.m. ET from Lucas Oil Stadium in Indianapolis.

Now, our experts and model have dissected the Colts vs. Chargers game and revealed their best bets, props, DFS picks, and more. Join SportsLine here to see what all our experts have to say about this crucial Monday Night Football game! Use promo code MONTH to get one month free!

Find each of our individual previews here:

SportsLine's simulation model says to be weary of the home underdog on Monday night!

The SportsLine model is fading a couple of Colts receivers among its top plays.

SportsLine NFL expert R.J. White has won 22 of his last 31 Chargers spread picks and just released a confident play for Monday night's game.

DFS millionaire Mike McClure shares his top NFL DFS plays for Chargers-Colts.

NFL insider Jason La Canfora is buying Justin Herbert on MNF and fading Nick Foles in his first start as Colts QB.

Make your own Week 16 MNF parlay using SportsLine's expert picks! Use promo code MONTH to get your first month of SportsLine for free!

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