Teams headed in opposite directions will meet on NFL Christmas Day 2021 when the Indianapolis Colts take on the Arizona Cardinals. The Colts (8-6) have won two in a row, while the Cardinals (10-4), who had the NFC's top seed just a couple of weeks ago, have dropped two in a row.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 8:15 p.m. ET. Arizona is favored by three points in the latest Colts vs. Cardinals odds from Caesars Sportsbook, while the Over-Under is 48. Before making you make any Colts vs. Cardinals picks, you NEED to check out the latest NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model knows Arizona's Kyler Murray continues to be one of the most dynamic quarterbacks in the league. He has 250-plus passing yards in four of his five home starts this season and is the only quarterback with 3,000-plus passing yards, 20 or more touchdowns and five or more rushing touchdowns in each of his past two seasons. Murray has eclipsed 300 yards passing three times in 2021, including a 400-yard performance in a 34-33 win over the Vikings in Week 2.

The model also knows the Colts are one of the hottest teams in the league, having won seven of their last nine games. A big reason for that is the play of running back Jonathan Taylor, an MVP-candidate who leads the league with 19 touchdowns, including 17 rushing. Taylor tore apart New England's defense last week to the tune of 170 yards rushing on 29 carries (5.9 average) and one touchdown, a 67-yarder with 2:01 remaining to seal the Colts' 27-17 victory.

Now, the model has set its sights on Colts vs. Cardinals on NFL Christmas Day 2021. We can tell you it's leaning Over the point total, and it also says one side of the spread has ALL the value! You ABSOLUTELY need to see it before locking in any Colts vs. Cardinals picks of your own.

So who wins Colts vs. Cardinals on Christmas? And which side of the spread has ALL the value? ... Join SportsLine right now to see which side of the Colts vs. Cardinals spread to back, all from the dialed-in NFL model that's up over $7,000 on top-rated NFL picks!