The San Francisco 49ers will try to snap a three-game losing streak when they meet the Indianapolis Colts on Sunday Night Football. Kickoff from Levi's Stadium in Santa Clara, Calif., is slated for 8:20 p.m. ET. Indianapolis is 2-4 this season, while San Francisco is 2-3.

The 49ers are 3.5-point favorites in the latest Colts vs. 49ers odds from Caesars Sportsbook, while the Over-Under is 41.5. Before you make your Colts vs. 49ers picks or any other NFL predictions, you MUST see what San Francisco expert Tom Fornelli has to say. 

The CBS national writer went a profitable 31-22 last season on his NFL best bets. What's more, he has demonstrated a particularly sharp eye for the 49ers. In fact, Fornelli has gone a stunning 15-6 on picks involving San Francisco. Anyone who has followed him is WAY UP.

After struggling early in the season, Indianapolis has been playing much better. Wide receiver Michael Pittman Jr. is a big part of the offense, and leads all Colts receivers with 31 receptions for 403 yards and one touchdown. He has five explosive plays and 19 first-down conversions. Pittman has 50 or more receiving yards in four of the past five games. His best game was an eight-catch, 123-yard performance against the Los Angeles Rams in Week 2.

Quarterback Jimmy Garoppolo will return from a calf injury for the Niners. Garoppolo has an 85 or better rating in three of his four starts this season. He will be looking for his fifth game in a row in 2021 with a touchdown pass, and is also looking for his third game in a row against an AFC South opponent with a 100 or better rating. For the season, he has completed 78-of-118 passes (66.1 percent) for 925 yards and five touchdowns. He has been intercepted twice, but has a rating of 96.9.        

For Colts vs. 49ers, we can tell you that Fornelli is leaning Over the total, but his much stronger play is on the spread. In fact, Fornelli has found a crucial X-factor that has him going BIG on one side! You ABSOLUTELY need to see it before locking in your own picks.

Who wins Colts vs. 49ers on Sunday Night Football? And which crucial X-factor makes one side of the spread hit hard? ... Join SportsLine right now to see which side of the Colts vs. 49ers spread to jump on, all from the expert who's 15-6 on Niners picks!