Colorado vs. West Virginia odds, line: 2025 college football picks for Week 11 predictions from proven model

Head coach Deion Sanders and the Colorado Buffaloes cross the country on Saturday for a Big 12 matchup against coach Rich Rodriguez and West Virginia. Both teams are 3-6 overall and 1-5 in the Big 12, leading only Oklahoma State.

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Kickoff from Mountaineer Field is at noon ET. The Mountaineers are 6.5-point favorites in the latest WVU vs. Colorado odds, while the over/under for total points scored is 52.5 via SportsLine consensus. 

Before making any Colorado vs. West Virginia picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 11 on a profitable 47-33 combined run on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated WVU vs. Colorado 10,000 times and the results are in. We can tell you that the model is leaning under, and it also says one side of the spread hits 60% of the time!

So who wins WVU vs. Colorado, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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