Colorado vs. USC line, picks: Advanced computer college football model releases selections for Friday matchup

The No. 8 USC Trojans host the Colorado Buffaloes in a Pac-12 matchup at 9:30 p.m. ET on Friday. USC is favored by 34 points at Caesars Sportsbook, while the over/under is set at 66 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Colorado vs. USC picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Colorado can benefit from USC's vulnerable defense. The Trojans are yielding more than 400 total yards per game, including the third-worst mark in passing defense. USC is also allowing 4.5 yards per carry on the ground, ranking in the bottom five of the conference in rushing defense from a yardage perspective. The model also knows USC is elite on offense. The Trojans are in the top seven of the country in yards per play, points per game, and third down efficiency this season. Caleb Williams is near the top of the nation in touchdowns, interception avoidance, and total yards from the quarterback position, and USC is facing a Colorado defense that is dead-last in the Pac-12 in total defense in 2022.

Now, it has set its sights on Colorado vs. USC. We can tell you the model is leaning Under the total, and it also says one side of the spread hits in more than 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Colorado vs. USC? And which side of the spread hits in more than 50% of simulations? ... Join SportsLine right now to find out which side of the Colorado vs. USC spread you should be all over Friday, all from the model on a roll on college football picks!