The Colorado Buffaloes (2-2) are set to host the No. 25 BYU Cougars (3-0) in a Big 12 showdown on Saturday. Kickoff at Folsom Field in Boulder is scheduled for 10:15 p.m. ET. The Buffs are looking to build off an impressive 37-20 win over Wyoming on Sept. 20. Head coach Deion Sanders made the move to Kaidon Salter at quarterback, and the Liberty transfer was solid in the win over Wyoming. The Cougars are undefeated with their three wins coming by an average of 38 points. BYU beat ECU 34-13 in its last outing. These programs met in last year's Valero Alamo Bowl, with BYU notching a dominant 36-14 victory.

BYU is a 6.5-point favorite in the latest Colorado vs. BYU odds, while the over/under for total points scored is 49.5. BYU is a -252 (risk $252 to win $100) favorite on the money line, with Colorado listed as a +203 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any BYU vs. Colorado picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 242-166-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 103.81 units ($10,381.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. BYU in their Week 5 matchup. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins BYU vs. Colorado in their Week 5 matchup at Folsom Field in Boulder and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 242-166-7, returning $10,382 for $100 bettors, betting on college football since 2023, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates