Colorado vs. Arizona prediction, odds, spread, line, start time: Proven expert releases college football picks, best bets, game props for Week 10 matchup at Folsom Field

The Colorado Buffaloes (3-5, 1-4) return home to take on the Arizona Wildcats (4-3, 1-3) in a Big 12 showdown on Saturday. Kickoff at Folsom Field in Boulder, Colo. is scheduled for 7 p.m. ET. The Buffs are looking to bounce back from a 53-7 blowout loss against Utah in Week 9. Kaidon Salter is expected to remain the starting quarterback for head coach Deion Sanders and the CU offense. The Wildcats are looking to bounce-back from a tough 31-28 loss to Houston on Oct. 18. Arizona is 4-3, while CU is 4-4 against the spread in 2025.

Arizona is a 3.5-point favorite in the latest Colorado vs. Arizona odds, while the over/under for total points scored is 52.5 (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Arizona vs. Colorado picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 261-182-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 102.5 units ($10,250.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Arizona in their Week 10 matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Arizona vs. Colorado in their Week 10 matchup at Folsom Field and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 257-182-7, returning $9,850 for $100 bettors, betting on college football since 2023, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about odds or picks changes/updates