The No. 21 Arizona Wildcats have beaten three straight ranked teams and now head to Boulder to face Deion Sanders' Colorado Buffaloes on Saturday afternoon. Arizona (6-3, 4-2 in the Pac-12) defeated former No. 19 UCLA, 27-10 last Saturday night, while Colorado (4-5, 1-5) fell to No. 16 Oregon State, 26-19. The Wildcats won this matchup last season, 43-20 and have won eight of the 12 matchups since Colorado joined the Pac-12 in 2011.

Kickoff is set for 2 p.m. ET on Saturday at Folsom Field. Arizona is favored by 9.5 points in the latest Wildcats vs. Buffaloes odds, while the over/under is set at 54.5 points, per SportsLine consensus. Before entering any Arizona vs. Colorado picks, you NEED to see the college football predictions from the model at SportsLine.

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The model has simulated Arizona vs. Colorado 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

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