The San Diego State Aztecs (3-1) are set to host the Colorado State Rams (1-3) in a Mountain West Conference showdown on Friday night. Kickoff at Snapdragon Stadium is scheduled for 10:30 p.m. ET on CBS Sports Network. The Aztecs are looking to win their third straight game after beating Northern Illinois 6-3 in their last outing. The Rams are aiming to bounce back from a 20-3 blowout loss to Washington State on Sept. 27. SDSU is 3-1 and CSU is 2-2 against the spread in 2025.

San Diego State is a 4.5-point favorite in the latest Colorado State vs. San Diego State odds, while the over/under for total points scored is 41.5. SDSU is a -237 (risk $237 to win $100) favorite on the money line, with Colorado State listed as a +194 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any San Diego State vs. Colorado State picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 245-172-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 99.53 units ($9,953.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado State vs. San Diego State in their Week 6 matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins San Diego State vs. Colorado State in their Week 6 matchup at Snapdragon Stadium in San Diego and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 245-172-7, returning $9,953 for $100 bettors, betting on college football since 2023, and find out!