The Week 8 college football schedule could be dubbed Separation Saturday as there are five ranked matchups to place Week 8 college football bets on. Three are in the SEC with Ole Miss vs. Georgia (-7), Alabama vs. Tennessee (+8.5) and LSU vs. Vanderbilt (-2.5) as the Tigers and Commodores play a ranked matchup for the first time since 1948. There's also one of the most stories rivalries in the sport with USC vs. Notre Dame, and the Irish are 9.5-point favorites, per the latest Week 8 college football odds after notching double-digit victories over the Trojans in each of the last two years.

Finally, the Big 12 will feature BYU vs. Utah (-3.5) also known as The Holy War, as this is their first Top 25 matchup since 2009. They first met in 1896, and the Utes lead the all-time series 62-36-4. The Cougars are one of 11 undefeated teams left standing, and their 5-1 spread record is sure to attract lots of Week 8 college football bets.

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Additionally, if you're looking for huge Week 8 college football lines to make predictions on, you're in luck. Over in the Big Ten, the No. 1 Buckeyes are favored by 25.5 points over Wisconsin, while third-ranked Indiana is a 27-point favorite over Michigan State in a rivalry known as The Battle for the Old Brass Spittoon (see more college football lines right here). 

Before making any college football picks for those games or others in Week 8, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 39-27 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 8 game, and the results are in. 

One of the college picks the model is high on during Week 8: Penn State (+3, 39.5) covers versus Iowa in a 7 p.m. ET Saturday kickoff well over 50% of the time. Another prediction: Missouri (-1.5, 44.5) covers against Auburn in over 70% of simulations Saturday at 7:45 p.m. ET, with the Over hitting nearly 60% of the time.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for four upsets in major games this week! 

So which college football teams should you back in Week 8, and which underdogs win outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception!

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