All 18 teams in the Big Ten will face off across nine conference matchups on the Week 7 college football schedule. That includes ranked matchups in Ohio State vs. Illinois and Oregon vs. Indiana. The No. 1 Buckeyes are favored by 16.5 points over the No. 17 Illini, per the Week 7 college football odds, while the third-ranked Ducks are 7-point favorites over the No. 7 Hoosiers. Meanwhile, the SEC isn't quite as active this week but still has some intriguing matchups for college football betting.

Arch Manning will get his first taste of the Red River Rivalry, with Texas 1-point underdogs  Oklahoma in the 121st meeting between the two as OU's John Mateer (hand) has been upgraded to probable. Alabama vs. Missouri is a top-20 matchup that has the Tide favored by 3.5 points according to the latest Week 7 college football lines. 

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Additionally, if you're looking for a huge college football line to make predictions on, you're in luck. Notre Dame is a 22.5-point favorite over NC State in a matchup with one of the largest Week 7 college football spreads (see more college football lines right here). 

Before making any college football picks for those games or others in Week 7, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 7 game, and the results are in. 

One of the college picks the model is high on during Week 7: Oregon (-7, 53.5) covers versus Indiana in a 3:30 p.m. ET Saturday kickoff (CBS/Paramount) nearly 60% of the time. Another prediction: LSU (-9, 44.5) covers against South Carolina in over 50% of simulations Saturday at 7:45 p.m. ET, with the Over hitting over 60% of the time.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for five underdogs to win straight-up, including an SEC shocker!

So which college football teams should you back in Week 7, and which five underdogs win outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception!

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