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College football odds, lines, spreads: Picks, predictions, betting advice for Week 3, 2025 from proven model

The SportsLine Projection Model, which has generated well over $2,000 for $100 college football bettors since its inception, has revealed its college football picks for Week 3

ByPublished: Sep 13, 2025 2:26PM UTC . 3 min read

After several teams put 70-plus points on the board last Saturday, the Week 3 college football spreads indicate scores could be much closer. Games like Georgia vs. Tennessee (+3.5), Pittsburgh vs. West Virginia (+7) and Notre Dame vs. Texas A&M (+6.5) all have college football lines of a touchdown or less. But if you still prefer games with large spreads, there is no shortage of those per the latest Week 3 college football odds. Oregon is -26.5 versus Northwestern, Alabama is -20.5 against Wisconsin, and Michigan is -27.5 versus Central Michigan.

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Some may find it easier to make Week 3 college football picks with narrow spreads, while others prefer the larger ones. Whatever your preference, hopefully the first few weeks of the year gave you insight to assist with cfb picks and predictions (see more college football lines right here). 

Before making any college football picks for those games or others in Week 3, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 31-19 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 3 game, and the results are in. 

One of the college picks the model is high on during Week 3: No. 7 Texas (-40.5) covers the massive spread at home versus UTEP in a 4:15 p.m. ET Saturday kickoff, with the Longhorns covering in well over 50% of simulations. Another prediction: Oregon State (+23.5) covers against No. 21 Texas Tech nearly 60% of the time on Saturday at 3:30 p.m. ET.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple upsets involving Power 4 teams going down!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

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Ross Kelly

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