Top-10 ranked teams coming off season-opening defeats will look to bounce back in the Week 2 college football schedule, and they have just the opponents to help them do that. Texas, Clemson and Alabama are all coming off losses, but the latest Week 2 college football lines have each of the three favored by at least 30 points. Meanwhile, there are college football spreads that are a bit closer for Saturday, including No. 11 Illinois vs. Duke (+2.5), UTSA vs. Texas State (+3.5) and West Virginia vs. Ohio (+3.5). No game has a slimmer spread than the SEC vs. ACC battle of Vanderbilt vs. Virginia Tech (-2.5).

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The highlight matchup of the slate features two of the most prestigious programs in the history of the sport. No. 15 Michigan vs. No. 18 Oklahoma sees the Sooners favored by 5.5 points at home, per the Week 2 college football odds (see more college football lines right here). 

Before making any college football picks for those games or others in Week 2, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college football spread picks, and was a profitable 27-16 combined on money-line and over/under picks in 2024. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 2 game, and the results are in. 

One of the college picks the model is high on during Week 2: Mississippi State (+6.5) covers versus No. 12 Arizona State at 7:30 p.m. ET on Saturday. Another prediction: Syracuse (-6.5) covers against UConn in well over 50% of the time on Saturday at noon ET.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for a ranked team to be upset by an unranked squad!

So which college football teams should you back in Week 2, and which underdog wins outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception!

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