College football odds, lines, spreads: Picks, predictions, betting advice for Week 14, 2025 from proven model

We've reached the final slate of 2025 college football games in the regular season, with rivalry matchups left and right to make Week 14 college football picks on. Ohio State vs. Michigan (+10), Miami vs. Pitt (+7) and Alabama vs. Auburn (+5.5) could all have bearing on the College Football Playoff, which only further incentivizes making any college football bets on them. There are also a number of intriguing non-conference matchups, such as Florida vs. Florida State, which has the Gators favored by 1.5 points in the latest Week 14 college football odds as the 'Noles need a win to become bowl-eligible.

Amongst the slimmest of college football spreads involve Baylor as 2.5-point favorites over Houston, while the largest line has Notre Dame favored by 31.5 points over Stanford. If interested in a high total with your Week 14 college football bets, East Carolina vs. FAU (+7, 66.5) has the highest over/under any game (see more college football lines right here). 

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Before making any college football picks for those games or others in Week 14, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 14 game, and the results are in. 

One of the college picks the model is high on during Week 14: Florida (-1.5, 49.5) covers against Florida State in almost 60% of simulations Saturday at 4:30 p.m. ET, with the Over hitting well over 60% of the time. Another prediction: Virginia Tech (+8.5, 52.5) covers on the road versus No. 17 Virginia at 7 p.m. ET on Saturday. The model projects the Hokies to cover nearly 60% of the time.

The model has also made the call on who wins and covers in every other FBS matchup, and it's identified multiple A-rated picks involving major teams! 

So which college football teams should you back in Week 14, and which A-rated picks are projected? ... Join SportsLine now to see who wins and covers every single game, all from the model that has simulated every game 10,000 times!

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