College football odds, lines, spreads: Picks, predictions, betting advice for Week 13, 2025 from proven model

There are just two more regular season weeks that you can make college football predictions on, and there are also just two ranked matchups for your Week 13 college football bets. USC vs. Oregon has the eighth-ranked Ducks favored by 9.5 points over the No. 16 Trojans as both teams still have aspirations of making the Big Ten Title Game. 

Elsewhere, the latest Week 13 college football odds have No. 8 Oklahoma favored by 5.5 points over No. 23 Missouri in a former Big 12 rivalry which has made its way over to the SEC. Mizzou won the first SEC matchup between the two last year as the Tigers seek back-to-back wins over OU for the first time since 1965-66.

Speaking of rivalries, there are several others you can choose from for your Week 13 college football picks. Tennessee vs. Florida (+4), Miami vs. Virginia Tech (+17.5), Texas vs. Arkansas (+8.5) should all be of interest to bettors in a slate devoid of elite matchups. If interested in a high total, the college football lines have UAB vs. South Florida (-21) with an over/under of 68.5, making it higher than any other FBS game (see more college football lines right here). 

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Before making any college football picks for those games or others in Week 13, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 13 game, and the results are in. 

One of the college picks the model is high on during Week 13: Kansas State (+17.5, 52.5) goes on the road to No. 13 Utah in a 4 p.m. ET Saturday kickoff and covers well over 70% of the time. Another prediction: No. 15 Georgia Tech (-2.5, 60.5) covers against Pitt in almost 60% of simulations Saturday at 7 p.m. ET, with the Over hitting over 50% of the time.

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for multiple underdogs outright winning, including two unranked teams defeating ranked squads! 

So which college football teams should you back in Week 13, and which Top 25 teams fall? ... Join SportsLine now to see who wins and covers every single game, all from the model that has simulated every game 10,000 times!

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